Compute Impact Deviation

Computes the impact deviation for each muscle, which is the difference between the observed impact score and the expected impact score for a muscle of that degree, expressed in standard deviations.

Usage

mskImpactDeviation(impact_scores, hg, null_scores = NULL)

Arguments

impact_scores

Named numeric vector of impact scores (from mskImpactScoreAll).

hg

An MSKHypergraph object.

null_scores

Optional matrix of null model impact scores (muscles x null_runs). If NULL, deviation is computed relative to a degree-based regression.

Value

A named numeric vector of impact deviations.

Details

The expected impact score is estimated from null model simulations or from a regression of impact score vs. degree.

References

Murphy AC et al. (2018) PLOS Biology.